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James D. (Jim) Neaton, Ph.D.

Professor
Division of Biostatistics

James Neaton has research interests in the design, conduct and analysis of clinical trials. He leads an international HIV clinical trials group (INSIGHT) and remains in involved in clinical trials aimed at the prevention of cardiovascular disease.  He teaches a course on clinical trials.   Dr. Neaton served as Editor of Controlled Clinical Trials from 1999-2003.  He has served on several national committees and advisory panels including theU.S. Public Health Service Panel on Clinical Practices for the Treatment of HIV Infection, the Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee, and the National Academy of Sciences, Committee on National Statistics Oversight Committee for Workshop on Handling Missing Data in Clinical Trials.

  • Ph.D., Biometry, University of Minnesota, 1984
  • M.S., Biometry, University of Minnesota, 1970

Research Interests:

Design, conduct, and analysis of clinical trials; application of statistical models to the analysis of data arising from intervention studies; and collaborative work in cardiovascular disease prevention and AIDS research

Research Projects (12)

James D. (Jim) Neaton

Mailing Address:

2221 University Avenue SE, Room 200
Minneapolis, MN 55414

Phone (Work): 626-9040

Email:

Website: http://www.biostat.umn.edu/~jim

Selected Publications:

The Strategies for Management of Antiretroviral Therapy (SMART) Study Group. CD4+ count - guided interruption of antiretroviral treatment. N Engl J Med 355:2283-2296,2006.


The Strategies for Management of Antiretroviral Therapy (SMART) Study Group.  Clinical outcomes in the SMART study after recommendation to re-initiate antiretroviral therapy for participants randomized to the CD4+ guided interruption strategy. Ann Intern Med 149:289-299, 2008.


Stamler J, Neaton JD. The Multiple Risk Factor Intervention Trial (MRFIT) – Importance then and now. JAMA 300:1344-1347, 2008.

Kuller LH, Tracy R, Belloso W, DeWit S, Drummond F, Lane HC, Ldergerber B, Lundgren J, Neuhaus J, Nixon D, Paton NI, Neaton JD. Activation of inflammatory and coagulation pathways is associated with mortality in patients with HIV infection. PLoS Medicine 5:e203, 2008.

Phillips AN, Neaton J, Lundgren J. The role of HIV in serious Diseases other than AIDS. AIDS 22:2409-2418, 2008.

Duprez DA, Kuller LH, Tracy R, Otvos J, Cooper D, Hoy J, Neuhaus J, Paton NI, Friis-Moler N, Liappis A, Neaton JD. Lipoprotein particle subclasses, cardiovascular disease and HIV infection. Atherosclerosis 207:524-529, 2009.

INSIGHT ESPRIT Study Group and SILCAAT Scientific Committee. Interleukin-2 therapy in patients with HIV infection. N Engl J Med 361:1548-1559, 2009.

Konstam MA, Neaton JD, Dickstein K, Drexler H, Komajda M, et al. Effects of high-dose versus low-dose losartan on clinical outcomes in patients with heart failure (HEAAL study): a randomized, double-blind trial. Lancet 374:1840-1848, 2009.


Neuhaus J, Jacobs DR, Jr., Baker JV, Calmy A, Duprez D, LaRosa A, Kuller LH, Pett S, Ritsola M, Ross MJ, Shlipak MG, Tracy R, Neaton JD.  Markers of Inflammation, coagulation and renal function are elevated in adults with HIV infection. J Infect Dis 201:1788-1795, 2010.


Phidisa II Writing Team for Project Phidisa.  A randomized factorial trial comparing 4 treatment regimens in treatment-naïve HIV-infected persons with AIDS and/or < 200 CD4+ cells/µL in South Africa. J Infect Dis 202:1529-1537, 2010.


Baker JV, Neuhaus J, Duprez D, Kuller lH, Tracy R, Belloso WH, De Wit S, Drummond F, Lane HC, Ledergerber B, Lundgren J, Nixon DE, Paton NI, Neaton JD.  Changes in inflammatory and coagulation biomarkers:  a randomized comparison or immediate versus deferred antiretroviral therapy in patients with HIV infection. J Acquir Defic Syndr 56:36-43, 2011.


Misrak G, DeGruttola V, Dixon D, Essex M, Halloran E, Hogan J, Grobler A, Kim S, McDermott J, McKaig R, Neaton JD.  Strengthening biostatistics resources in Sub-Saharan Africa:  research considerations through U.S. partnerships. Stat Med  30: 695-708, 2011.


Morrison BW, Cochran CJ, White JG, Harley J, Kleppinger CF, Liu A, Mitchel JT, Nickerson DF, Zacharias CR, Kramer JM, Neaton JD.  Monitoring the quality of conduct of clinical trials: a survey of current practices. Clinical Trials 8:342-349, 2011.


INSIGHT Influenza Study Group.  Surveillance of illness associated with pandemic (H1N1) 2009 virus infection among adults using a global clinical site network approach: the INSIGHT FLU 002/FLU 003 Studies.  Vaccine 295:B56-B62, 2011.


 


 

Professional Experience:

Professor, Biostatistics Division, School of Public Health, University of Minnesota, 1995-Present


Adjunct Professor of Infectious Disease & International Health, Department of Medicine


Associate Professor, Biostatistics Division, School of Public Health, University of Minnesota, 1990-1995


Assistant Professor, Biostatistics Division, School of Public Health, University of Minnesota, 1985-1990


Research Fellow, Biometry Division, School of Public Health, University of Minnesota, 1973-1985  


USPHS Officer, National Heart and Lung Institute, NIH, 1970-1972

Honors:

Pi Mu Epsilon


Delta Omega Honorary Public Health Society


Leonard M. Schuman Excellence in Teaching Award


Fellow, American Statistical Association


Fellow, Society for Clinical Trials


University of Minnesota Academic Health Center Academy for Excellence in Health Research


 

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