Weihong Tang's Research
Epidemiologic Study of Sick Sinus Syndrome
Sick sinus syndrome (SSS) accounts for 30-50% of pacemaker implantations in the US. Still, little is known about its distribution in the population, its risk factors, and its impact on cardiovascular outcomes and mortality. The proposed research will use available data from two large cohort studies to answer relevant questions about the epidemiology of SSS. Results from this study will provide a better understanding of SSS and cardiac electrophysiology, which could lead eventually to new preventive and therapeutic approaches for this and other cardiac conditions such as atrial fibrillation and cardiac conduction disturbances.
Epidemiology of calcineurin gene polymorphisms, serum calcineurin, and LVH
The objective of this study is to evaluate the utility of serum calcineurin protein and enzymatic activity as biomarkers for LVH at the population level and to identify variants in genes involved in the calcineurin pathway that contribute to the risk of LVH.
Genetic Epidemiological Study of Venous Thromboembolism and Hemostatic Factors
This study will provide greater understanding of the genetic determinants of venous thromboembolism and it intermediate phenotypes at the population level and potentially provide new opportunities for the prevention or treatment of venous thromboembolism.
Identifying Epidemiological Risk Factors of Abdominal Aortic Aneurysm
Data from this study will provide new insights in the biological determinants of AAA, and potentially improve prevention and early management of AAA to prevent ruptures.
Multi-Ethnic Study of Atherosclerosis (MESA) - Field Center
The primary goals of this proposal are to maintain the MESA cohort for ascertainment of incident events through 2015 and to perform an additional in-person clinical examination.