Presented by Ryan Demmer, PhD
Division of Epidemiology and Community Health
Heart failure (HF) is characterized by venous congestion and systemic inflammation. Splanchnic venous congestion may alter intestinal barrier function and gut microbiota composition leading to dysbiosis (i.e., intestinal overgrowth of pathogenic bacteria, and reduced microbial diversity) along the digestive tract. Accordingly, altered barrier function and digestive tract dysbiosis have been hypothesized as potential causes of endotoxemia and the inflammatory and oxidative state seen in heart failure patients. Left ventricular assist devices (LVAD) and heart transplantation (HT) are the mainstay of therapy for advanced HF. The effect of these therapies on microbial milieu, endotoxemia, inflammation and oxidative stress is unknown. We are actively investigating the influence of LVAD and HT on the digestive tract microbiome as well as the interplay between heart failure phenotype, gut and oral microbiome and the inflammatory state among a cohort of heart failure patients. This seminar will outline the rationale for these investigations and present preliminary results from our studies.
All faculty, staff, and students welcome! Light refreshments will be served.