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Elizabeth V. Wattenberg, Ph.D.
Associate Professor
University of Minnesota School of Public Health
Ph.D., Toxicology, Massachusetts Institute of Technology
B.S., Molecular Biophysics and Biochemistry, Yale University
Courses
PubH 6104, Environmental Health Effects: Introduction to Toxicology
PubH 6161, Regulatory Toxicology
PubH 8160, Advanced Toxicology
PubH 8161, Current Literature in Toxicology
Fall 2009
3104: Environmental Health Effects: Introduction to Toxicology
Fall 2009
8163: Toxicology
Fall 2009
6104: Environmental Health Effects: Introduction to Toxicology
Fall 2009
8160: Advanced Toxicology
Spring 2010
6161: Regulatory Toxicology
Research Interests:
Molecular mechanisms by which different types of carcinogenic agents interfere with the signaling pathways that control cell fate and function; how both genotoxic and nongenotoxic carcinogens modulate signaling pathways that are mediated by members of the mitogen activated protein kinase family; how environmental chemicals affect carcinogenesis.
Recent Publications:
Zeliadt NA, Mauro LJ, and Wattenberg EV. Reciprocal Regulation of Extracellular Signal Regulated Kinase 1/2 and Mitogen Activated Protein Kinase Phosphatase-3. Toxicol. Appl. Pharmacol., 232:408-417 (2008).
Wattenberg E. V. Palytoxin: Exploiting a novel skin tumor promoter to explore signal transduction and carcinogenesis. American Journal of Physiology-Cell Physiology, 292:C24-32, 2007.
Warmka, J., K., Mauro L. J., and Wattenberg E. V. Mitogen Activated Protein Kinase Pphosphatase-3 is a Tumor Promoter Target in Initiated Cells that Express Oncogenic Ras. J. Biol. Chem. 279:33805-33902, 2004.
Zeliadt, N. A., Warmka, J., K., Winston, S., E., Kahler R., Westendorf, J.J., Mauro, L.J., and Wattenberg E. V. Tumor Promoter-Induced MMP-13 Gene Expression in a Model of Initiated Epidermis. Biochem. Biophys. Res. Comm. 317:570-577, 2004.
Zeliadt, N. A., Warmka, J. K., and Wattenberg E. V. Mitogen Activated Protein Kinases Selectively Regulate Palytoxin-Stimulated Gene Expression in Mouse Keratinocytes. Toxicol. Appl. Pharmacol. 192:212-221, 2003.
Wichmann, A. E. , Thomson, N. M., Peterson, L. A., and Wattenberg, E. V. Genotoxic Methylating Agents Modulate Extracellular Signal Regulated Kinase Activity Through MEK-dependent, and Gluthatione-, DNA Methylation-independent Mechanisms in Lung Epithelial Cells. Chem. Res. Toxicol. 16:87-94, 2003.
Warmka, J. K., Winston, S. E., Zeliadt, N.A., and Wattenberg, E.V. Extracellular Signal-regulated Kinase Transmits Palytoxin-stimulated Signals Leading to Altered Gene Expression in Mouse Keratinocytes. Toxicol. Appl. Pharmacol. 185:8-17, 2002.
Ellerbroek, S. M., Halbleib, J. M., Benavidez, M., Warmka, J. K., Wattenberg, E. V., Stack, M. S., and Hudson, L. G. Phosphatidylinositol 3-Kinase Activity in Epidermal Growth Factor- Stimulated Matrix Metalloproteinase-9 Production and Cell Surface Association. Cancer Res. 61:1855-1861 (2001).
Cross, D.P., Ramachandran, G., and Wattenberg, E.V. Mixtures of Nickel and Cobalt Chlorides Induce Synergistic Cytotoxic Effects: Implications for Inhalation Exposure Modeling. Ann, Occupational. Hyg. 45:409-418 (2001).
McCawley, L.J., Li, S., Benavidez, M., Halblieb, J., Wattenberg, E.V., and Hudson, L.G. Elevation of Intracellular Cyclic Adenosine 3',5'-monophosphate Inhibits Growth Factor-Mediated Matrix Metalloproteinase (MMP)-9 Induction and Keratinocyte Migration. Mol. Pharmacol. 58: 145-151 (2000).
Professional Experience:
2000-present, Associate Professor and Director of Graduate Studies, Division of Environmental Health Sciences, School of Public Health, University of Minnesota
1994-2000, Assistant Professor, Division of Environmental Health Sciences, School of Public Health, University of Minnesota
1990-1994, Environmental Toxicologist
Section of Health Risk Assessment, Minnesota Department of Health
1989-1990, Postdoctoral Fellow, Gray Freshwater Biological Institute, University of Minnesota
Honors:
1998, Co-chair Cell Signaling and Apoptosis session at the Mechanisms of Toxicity Gordon Conference
1999, National Institutes of Health Special Emphasis Panel Study Section
2002, EPA STAR Toxicology Fellowship Panel
2003-present, Editorial Board of Toxicology and Applied Pharmacology
2003, Pathobiology-3 Panel, Department of Defense Breast Cancer Research Program
2004-2007, Cell Function & Metabolism/Cell Transport, Physiology & Metabolism Study Section, American Heart Association
Contact
Mailing Address:
Division of Environmental Health Sciences
Mayo Mail Code #807, 420 Delaware Street SE
Minneapolis, MN 55455
Phone (Work): (612) 626-0184
Email: watte004@umn.edu
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Last modified on Thursday, January 22, 2009