John E. Connett PhD » Faculty

Research Interests:Clinical trials in cardiovascular disease, ophthalmology and pulmonary disease, case-control studies, estimation of odds ratio, random effects models, coefficient-of-variation models for laboratory data, and statistical computing

Professor, Biostatistics

Home Division of Biostatistics A464 Mayo Building, MMC 303 Minneapolis MN 55455 United States Home Phone: 612-626-9010
Photo of John E. Connett PhD

Biography:

John Connett has research interests in clinical trials in pulmonary disease, smoking, ophthalmology, and cardiovascular disease; case-control studies; estimation of odds ratio; random effects models; coefficient-of-variation models for laboratory data; and statistical computing.

  • Ph.D., Mathematics, University of Maryland, 1969
  • A.M., Mathematics, University of Missouri, 1964
  • A.B., Mathematics, University of Missouri, 1963

Research Projects:

COPD Clinical Research Network – Data Coordinating Center
Principal Investigator: John E. Connett
Funding Agency: NIH Nat’l Heart, Lung, and Blood Inst.
COPD Clinical Research Network – Data Coordinating Center

COPD Clinical Research Network Data Coordinating Center
Principal Investigator: John E. Connett
Investigators: John E. Connett, PhD Christine Wendt, MD
Funding Agency: National Heart, Lung and Blood Institute
The COPD Clinical Research Network, sponsored by the National Heart, Lung and Blood Institute, has the mission of carrying out clinical trials of new therapies or preventatives for COPD and to slow progression of COPD and test improved ways to treat acute COPD exacerbations. The Network is comprised of 10 Clinical Centers and a Data Coordinating Center (DCC). The Network is expected to conduct several trials simultaneously. The specific responsibilities of the DCC include: assisting in designing, planning and conduct of clinical trials; providing Manuals of Procedures and case report forms for each study; provide randomization schedules and procedures; created and use interactive data entry software and procedures; producing monitoring reports on recruitment, follow-up, adverse events, mortality, treatment efficacy, and other data; assist clinic investigators in the preparation of manuscripts and presentations.

Feasibility Studies on Retinoid Treatment of Emphysema (FORTE)
Principal Investigator: John E. Connett
Funding Agency: NIH Nat’l Heart, Lung, and Blood Inst.
Feasibility Studies on Retinoid Treatment of Emphysema (FORTE)

Genome-Wide Associations Environmental Interactions in the Lung Health Study
Principal Investigator: John E. Connett
Funding Agency: Johns Hopkins University
Genome-Wide Associations Environmental Interactions in the Lung Health Study

Graduate Training in Biostatistics
Principal Investigator: John E. Connett
Funding Agency: NIH Nat’l Inst of Allergy & Infect Dis
Graduate Training in Biostatistics

Selected Publications:

  • Kasuga, I., Ruan, J., Connett, J.E., Anthonisen, N.R., and Sandford, A.J. Lack of association of Human Leukocyte Antigen-B7 with COPD and rate of decline in lung function. Respir Med, 99(12):1528-1533, 2005.
  • Guo, X., Pan, W., Connett, J.E., Hannan, P.J., and French, S.A. Small-sample performance of the robust score test and its modifications in generalized estimating equations. Statistics in Medicine, 24:3479-95, 2005.
  • He, J.-Q., Burkett, K., Connett, J.E., Anthonisen, N.R., Par, P.D., and Sandford, A.J. Interferon gamma polymorphisms and their interaction with smoking are associated with lung function. Hum Genet, DOI 10.1007/s00439-006-0143-z, 2006 (electronic publication).
  • Herpel, L.B., Kanner, R.E., Lee, S.M., Fessler, H.E., Sciurba, F.C., Connett, J.E., and Wise, R.A. for the Lung Health Study Research Group and the National Emphysema Treatment Trial Research Group. Variability of spirometry in chronic obstructive pulmonary disease: results from two clinical trials. Am J Respir Crit Care Med, 173:1106-1113, 2006.
  • Wallace, A.M., He, J.Q., Burkett, K., Ruan, J., Connett, J.E., Anthonisen, N.R., Pare, P.D., and Sandford, A.J. Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: An association study. To appear in Respiratory Research.
  • Man, S.F.P., Connett, J.E., Anthonisen, N.R., Wise, R.A., Tashkin, D.P., and Sin, D.D. C-Reactive protein and mortality in chronic obstructive pulmonary disease. To appear in Thorax.

Technical Reports:

  • rr93-007.ps.Z and rr93-007figs.ps.Z
    Cowles, M.K., Carlin, B.P. and Connett, J.E.,
    Bayesian Tobit modeling of longitudinal ordinal clinical trial compliance data with nonignorable missingness,
    Research Report 1993-7, Division of Biostatistics, University of Minnesota, 1993
    J. Amer. Statist. Assoc., 91, 86-98, 1996.