Research Studies

ACHIEVE (Aging and Cognitive Health Evaluation in Elders) is studying the relationship between cognitive decline and incident dementia.

Examining the influence of physical activity on the gut microbiome. Determining how walking may influence the bacteria living in the gut of people with prediabetes. Researchers are recruiting adults in the Twin Cities metro area to participate in this study.

Beginning in 1986, ARIC is a multicenter study investigating the cause of atherosclerosis, its clinical outcomes, and variation in cardiovascular risk factors, medical care, and disease by race, gender, location and date.

The Coronary Artery Risk Development in Young Adults (CARDIA) Study is a study examining the development and determinants of clinical and subclinical cardiovascular disease and their risk factors. It began in 1985-6 with a group of 5115 black and white men and women aged 18-30 years.

DISCOVERY (Determinants of Incident Stroke Cognitive Outcomes and Vascular Effects on Recovery) Network is investigating the mechanisms of post-stroke cognitive impairment and dementia to reduce rates of cognitive and functional disability among high-risk populations in the United States.

MESA is studying the early stages of atherosclerosis, a condition in which cholesterol and other substances stick to the walls of arteries and blood and can cause a variety of health problems, such as heart disease and stroke, in diverse race and ethnic groups.

mGlide investigates the effectiveness of mobile technology in hypertension treatment. mGlide is a heart health study that gives people a blood pressure machine to measure blood pressure at home.

MrOS is a cohort of 5,994 elderly US men formed primarily to quantify the determinants of fracture in men. The cohort also yields a seminal opportunity to study men as they progress through a critical period of life during which problems of aging remain poorly understood.


This phase of the study followed the TIDES children between the ages of four and six years old as well as their mothers. TIDES II was important because it allowed us the opportunity to extend our knowledge beyond pregnancy and learn about the potential effects of prenatal and postnatal phthalates on the development of young children. We examined how the environment and events occurring between ages four and six, as well as when the child was in utero, affected a child’s growth, well-being, and behavior.


In 2016, TIDES families began participating in the Environmental Influences on Child Health Outcomes (ECHO) Cycle 1 Program funded by NIH. The goal of ECHO was to understand the effects of a broad range of early environmental exposures on child health and development from birth through adolescence. ECHO’s five key health outcomes were pre-, peri-, and postnatal; upper and lower airways; obesity; neurodevelopment; and positive health. At our University of Minnesota TIDES/ECHO cohort site, we followed the TIDES children until they were 10 years old and conducted physical measurements, neurocognitive function, venous blood collection, demographic data collection, and psychosocial assessments with these participants.



TIDES III is a newly funded phase of measurements that is being conducted when the TIDES children are 12 and 14 years old. TIDES III seeks to determine if common chemicals in our environment affect adolescent lung health, including lung function and inflammation. These chemicals can also affect hormones like testosterone and estrogen; therefore, we will determine if they affect male and female lung health differently. Similar to TIDES II and TIDES ECHO, the TIDES III study visits will include surveys, body measurements (height and weight), biospecimen collection (urine and blood), and airway measurements (spirometry and FeNO, which is short for Forced exhaled Nitric Oxide). This will allow us to examine sex-specific outcomes in adolescent airway health.

© 2015 Regents of the University of Minnesota. All rights reserved. The University of Minnesota is an equal opportunity educator and employer. Privacy Statement