Category: Environment/Exposures

Tackling a Persistent Pollutant

Associate Professor Matt Simcik developed a process to keep hazardous PFCs — now called PFAS (perfluoroalkyl substances) — from traveling through aquifers to drinking water sources and ecosystems.

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Still Smoking

Many Americans don’t need to watch reruns of Mad Men to recall a time when airplanes had smoking “sections,” cigarettes were advertised on billboards and available for purchase at vending machines, and lighting up was such a mainstay of the bar scene that the smell of smoke clung to your clothes for days.

Man smoking cigaretteIn the mid-20th century, about half of all Americans smoked. But those numbers began to change after the 1964 Surgeon General’s Report linked smoking to cancer. SPH Professor Leonard Schuman, long-time head of the then Division of Epidemiology, played a key role in drafting that report.

The downward trend continued after successful national lawsuits against the tobacco companies, including Minnesota’s State of Minnesota v. Philip Morris, an unprecedented $6.6 billion win in 1998 that alleged tobacco companies were hiding the hazards of smoking and targeting children as new customers. The suit relied on the research and testimony of SPH researchers and generates $200 million annually —forever —for public health efforts across the state.

By 2005, 20 percent of the U.S. population smoked. In 2015, that number was down to 15 percent.

But smoking in 2017 is still the leading cause of preventable disease and death in the United States. It’s a significant risk factor for cardiovascular disease, cancer, respiratory diseases, and diabetes — chronic diseases that are responsible for 1-in-5 deaths each year. About 50 percent of all U.S. adults have a chronic disease today, and that number is forecasted to increase to around 65 percent by 2030.

These sobering statistics drive School of Public Health faculty to investigate the social determinants of smoking, to increase what we know about emerging types of tobacco use, and to lead education efforts to prevent smoking.

Evidence for Quitting

While health experts agree that quitting smoking is the single best thing you can do for your health, a recent SPH study found that smoking leaves an imprint on our genes — even for people who had quit smoking decades ago.

“When we engage in certain health risk behaviors, it’s common to tell ourselves that we can always quit and there won’t be long-lasting effects,” says genomics researcher and Professor Ellen Demerath, who was an author on the study. “While it’s true that our research showed former smokers had a more normal epigenetic profile than current smokers, the fact is there were still shadows on their genes that didn’t go away, even 30 years later.”

That’s not to suggest that quitting smoking doesn’t have very tangible health benefits. The risk of having an abdominal aortic aneurysm drops when smokers quit, according to a 2016 study by cardiovascular health researcher and Associate Professor Weihong Tang. Her research found that while middle-aged smokers had a roughly 1-in-9 chance of developing an abdominal aortic aneurysm in their lifetime, that risk declined by 29 percent for the people who quit smoking during the course of the study. And longer-term quitters — those who had been former smokers for 25 years or more — had an even lower risk.

Tobacco and Cultural Norms

When it comes to quitting smoking, social and cultural factors can make that exceptionally difficult, especially for U.S. veterans, blue collar workers, and American Indians.

Man smoking cigarette“There’s a lot of socializing in the military that occurs around smoking, which makes quitting hard — if you take a smoking break, you can hang out with your friends,” says Assistant Professor Rachel Widome, who investigates social determinants of health, including smoking use and cessation amongst veterans of the wars in Iraq and Afghanistan. After military discharge, vets take their smoking habit with them.

Smoking cessation researcher and Associate Professor Deborah Hennrikus conducted a study in small manufacturing companies in five counties in the Minneapolis/St. Paul area that assessed a work safety/health promotion program to motivate smokers to use smoking cessation resources already available to them through their health insurance.

Low-cost interventions like these can be a win-win for employees and companies, “because employees who smoke are sick more often and increase the cost of health insurance and other costs borne by the company,” Hennrikus says.

In Minnesota’s American Indian reservations, smoking rates can be as high as 60 percent. Emerita Professor Jean Forster — who has worked on tobacco interventions for 30 years and was instrumental in the 1990, first-of-its-kind legislation that banned cigarette vending machines in public places — is now exploring community tobacco policies on reservations. She regularly works with the American Indian Cancer Foundation — directed by Kristine Rhodes, MPH ’00 — to better understand the complexities of cultural and tribal regulations and to forge collaborative solutions. “Reservation residents have strong feelings about outsiders leading change and tobacco has deep cultural significance,” says Forster.

Global Advocates

“Today, more Americans are ex-smokers than current smokers and that is a great victory,” says tobacco policy researcher and Professor Harry Lando. But he is far less encouraged by increasing smoking in many low- and middle-income countries.

Lando, who was an editor of the Surgeon General’s Report on Smoking and Health in 1988, has now shifted his anti-tobacco work to developing countries — including Indonesia, a so-called “smoker’s paradise” where 70 percent of men smoke. “One billion deaths from smoking are projected across the world in the 21st century,” says Lando. “That’s mostly in low- and middle-income countries. If we could bend that curve by even 10 percent, we can have an incredible public health impact.”

But it’s a big challenge, says Monique Muggli, MPH ’99, associate legal director for the Campaign for Tobacco-Free Kids. “Globally, the tobacco industry is the biggest threat in decreasing and preventing tobacco use. It has exported its play book from the United States and other high-income countries to emerging economies in order to recruit young tobacco users and influence governments.”

Lando has successfully lobbied the World Conference on Tobacco or Health to hold more of their conferences in the developing world. He wants the problem to be witnessed first-hand by political leaders, who generally don’t see smoking as a high priority when compared to other public health challenges, including lack of access to clean water.

Ultimately, Lando sees smoking as a human rights issue — it denies people the right to enjoy sound health and to live in a healthy environment that’s free from secondhand smoke, which accounts for an estimated 600,000 deaths around the globe every year.


E-cigarettes and Smokeless Tobacco: The Next Unknown Public Health Frontier

Cigarette smoking rates are down across the United States, so tobacco companies are finding new and increasingly popular ways to market their product. “The use of other tobacco products, including e-cigarettes, is picking up,” says Assistant Professor Rachel Widome. “We don’t know yet if these alternatives are healthier, or if users, especially teenagers, will eventually switch to cigarette smoking.”

Associate Professor Irina Stepanov works with research associate Vipin Jain to determine chemicals found in cigarettes and smokeless tobacco.
Associate Professor Irina Stepanov works with research associate Vipin Jain to determine chemicals found in cigarettes and smokeless tobacco.

Is Vapor Safer?

According to a report in December 2016 from the United States Surgeon General, electronic cigarettes — which turn nicotine into inhalable vapor — are gaining popularity with young people. The 2016 Minnesota Student Survey (MSS) showed that nearly 20 percent of 11th grade students reported using e-cigarettes in the past 30 days, while only 8 percent smoked cigarettes. Recent research, published in Pediatrics, says that this spike in e-cigarette use has been powered by flavors that taste like gummy bears and bubble gum.

While adults aren’t using e-cigarettes in such high numbers, a survey published in the International Journal of Environmental Research and Public Health found that 30 percent of surveyed current and former adult users turned to e-cigarettes to cut back on or quit smoking cigarettes.

While tobacco companies like to market the idea that these products are safer than traditional cigarettes, there have been no definitive answers and the rise in usage is of great concern to public health professionals. The Surgeon General’s report, for example, cites studies in animals that suggest that e-cigarettes can harm developing brains of teenagers.

Chewing Chemicals

Smokeless tobacco products
Smokeless tobacco products

And it’s not just e-cigarettes that are gaining popularity. Today, 6.7 percent of American males use smokeless tobacco, up from 4 percent in 2000, according to the Centers for Disease Control and Prevention. While smokeless (chewing) tobacco is associated with lower risk of disease than cigarettes, its use is not risk free. For instance, N’-nitrosonornicotine (NNN), a chemical found in smokeless tobacco, can cause oral cancer and some smokeless users are exposed to high levels of this chemical from their favorite smokeless tobacco brand. SPH faculty Irina Stepanov and Silvia Balbo have contributed to understanding these risks by conducting studies in tobacco products, tobacco users, and laboratory animals.

“When people buy smokeless tobacco products, they don’t really know what is in the product and if it contains cancer causing chemicals,” says Stepanov.

That means that consumers can be unknowingly endangering their health. “We can’t yet predict who is at higher risk to develop cancer from smokeless tobacco use and how much exposure it will take for someone to end up with cancer,” says Stepanov. “The main message from a public health standpoint has to be to not use any tobacco products.”

Investigating Food Outbreaks

Every year, Minnesota experiences more than 40 foodborne disease outbreaks. The summer months see scores of Salmonella cases or E. coli poisoning, while winter brings norovirus infections by the droves.

SPH student, and Team D member, Tess Peterson (left) with Team D director Carlota Medus (MPH '99, PhD '06).
SPH student, and Team D member, Tess Peterson (left) with Team D director Carlota Medus (MPH ’99, PhD ’06).

The Minnesota Department of Health (MDH) is continuously collecting information on potential foodborne illness outbreaks via routine surveillance, or when a patient, provider, or institution reports a suspected outbreak.

Investigating the source of those outbreaks takes hundreds of hours, many of which are conducted by Team D (“D” for diarrhea), a group in MDH’s Foodborne Diseases Unit made up in large part by School of Public Health students. Team D students are hired to investigate, document, and track outbreaks of foodborne diseases in the state. The program was founded by SPH professor and foodborne disease expert Craig Hedberg in 1996 and has continued to evolve under the direction of Carlota Medus MPH ’99, PhD ’05, and Kirk Smith for the past 21 years.

Identifying an Outbreak

“This is the true epidemiology experience,” says Medus, supervisor of the Foodborne Diseases Unit at MDH. “As part of Team D, you learn everything to do during an outbreak at the state level, and get a complete picture of what happens when you detect an outbreak.”

Amy Saupe (MPH '16) analyzes data from a recent outbreak.
Amy Saupe (MPH ’16) analyzes data from a recent outbreak.

Currently, all of the Foodborne Disease Unit epidemiologists, including Medus, are SPH alumni, and were part of Team D as students before getting hired by MDH. 

“Team D helps with every step of the investigation,” says Medus. Initially, a Team D worker will call a patient and take a detailed epidemiological history of their food intake and possible exposures. “They’ll ask about everything that happened in the seven days before symptoms began,” says Medus.

And, Medus says, Team D members often break open a case. “Since the students are the ones on the phone with patients, they’re often the first to notice if a certain restaurant has been mentioned more than once.”

Unique Experience

Having the chance to solve the mystery of an outbreak is what attracted Krista Bryz-Gornia to Team D. The first-year epidemiology MPH student heard about the program during a student fair before she started in SPH and knew she wanted to be a part of the team.

SPH student and Team D member Luke Magnuson conducts phone interviews.
SPH student and Team D member Luke Magnuson conducts phone interviews.

“I love that we get to see an outbreak or a case from beginning to end. It’s exciting to talk to other student workers when there’s an outbreak and say, ‘Did your patient eat at this restaurant?’ ‘Did they have this symptom?’”

As a fluent Spanish speaker, Bryz-Gornia has conducted bilingual interviews and says MDH has been flexible in letting her balance work and school. Team D staff members work about 20 hours a week from 9 a.m. to 8:30 p.m., often contacting patients in the evening to get information about their illness and symptoms.

“Team D has been a perfect complement to my public health education,” Bryz-Gornia says.

In addition to MDH, the program’s alumni work across the country in such institutions as the U.S. Department of Agriculture and the CDC.

Andrew Beron, MPH ’14, was a Team D member and is now an epidemiologist for the U.S. Virgin Islands Department of Health on the island of St. Croix, where he helps perform Zika surveillance. Beron says his time at Team D was helpful in preparing him for a career in the field.

“Team D is something students at other schools of public health don’t get,” says Beron. “It helped me build so much confidence as an investigator.”

Minnesota Leads the Way

That confidence is what sets Minnesota’s SPH apart from other institutions. “By the mid-1990s it became clear that foodborne infections weren’t going away,” says Hedberg. “What we wanted to do with foodborne disease surveillance was create a student worker team that could participate in surveillance and do routine interviews with individual cases, then the students have both practical experience and the opportunity to work with data they’ve collected.”

Hedberg says other state departments of health and even the CDC have taken note of Team D’s efficiency.

“We developed the model, and others have tried to replicate it,” says Hedberg. “The partnership between the SPH and MDH is still one of the biggest draws to our school for students who want to work in epidemiology.”

Opioid Use and Pregnancy

Mother and babyNon-medical use of opioids has skyrocketed.

To further understand the epidemic, SPH Associate Professor and maternal health policy expert Katy Kozhimannil is researching how opioid use affects reproductive-age women, pregnant women, and infants.

She found that 1.5 million reproductive-age women and 50,000 pregnant women across the U.S. reported using prescription opioids for non-medical purposes in the past year. And nearly half of these pregnant women got opioids from their doctor.

A second study found that women who use opioids for non-medical purposes during pregnancy also are more likely to use other substances (such as alcohol or marijuana) and have higher chances of reporting symptoms of depression or anxiety.

A third paper found that this increase in non-medical opioid use during pregnancy has also led to a increase in U.S. babies born with Neonatal Abstinence Syndrome, or opioid withdrawal. From 2003–2014, the number of babies born with opioid withdrawal grew four times in urban areas and seven-fold in rural areas.

“Every infant who is withdrawing has a mom who was exposed to opioids and, possibly, didn’t have access to the treatment and support she needed,” says Kozhimannil.

“The challenge is that pregnant women can’t just stop taking opioids — both because of their dependence, but also because without opioids, a baby could withdraw in utero and possibly die.”

The ultimate goal is prevention. “Early recognition of non-medical opioid use can allow for tapering off the drug prior to planned pregnancies. When detected during pregnancy, opioid dependence can be appropriately treated to reduce its pregnancy-related health risks,” says Kozhimannil. “This research emphasizes the importance of targeted detection and treatment efforts that address a woman’s full range of needs.”

Avoiding Skin Cancer

Associate Professor DeAnn Lazovich
Associate Professor DeAnn Lazovich

Skin cancer rates have been increasing steadily in the United States. We asked cancer researcher DeAnn Lazovich to explain the increase in melanoma, the deadliest kind of skin cancer.

“75 percent or more of all skin cancer deaths are related to melanoma, one cancer that is largely preventable. The reason the trends are increasing is due to excessive time spent in the sun and, more recently, the use of tanning beds.”

Lazovich points to a number of things that put people at risk for melanoma. “There are risk factors you inherit like eye color, skin color, and lighter hair color — and you’re born with that. But there are modifiable risk factors we’re talking about exposure to ultraviolet radiation, particularly the type of sun exposure that leads to sunburn.”

She says you can protect yourself in a number of ways when in the sun, including:

  • Wear protective clothing, such as shirts with long sleeves, and a hat that covers your face
  • Use a sunscreen with a SPF of 30 or higher
  • Avoid tanning beds

“Ultraviolet radiation emitted from tanning beds is actually stronger than the sun and that might be one reason why we now know it increases the risk of melanoma,” Lazovich says.


MnTAP wins Progress Minnesota Award

The Minnesota Technical Assistance Program (MnTAP) was awarded Finance & Commerce’s 2017 Progress Minnesota Award, which showcases economic development happening across the state. The program is housed in the University of Minnesota School of Public Health’s Environmental Health Sciences Division,

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